Therapeutic Actions of a New Synthetic Vasoactive and Natriuretic Peptide, Dendroaspis Natriuretic Peptide, in Experimental Severe Congestive Heart Failure
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چکیده
منابع مشابه
Therapeutic actions of a new synthetic vasoactive and natriuretic peptide, dendroaspis natriuretic peptide, in experimental severe congestive heart failure.
Dendroaspis natriuretic peptide (DNP), a recently discovered peptide, shares structural similarity to the other known natriuretic peptides, ANP, BNP, and CNP. Studies have reported that DNP is present in human and canine plasma and atrial myocardium and increased in plasma of humans with congestive heart failure (CHF). In addition, synthetic DNP is markedly natriuretic and diuretic and is a pot...
متن کاملRenal actions of synthetic dendroaspis natriuretic peptide.
BACKGROUND Dendroaspis natriuretic peptide (DNP), recently isolated from the venom of the green Mamba snake Dendroaspis angusticeps, is a 38 amino acid peptide containing a 17 amino acid disulfide ring structure similar to that of atrial natriuretic peptide (ANP), brain natriuretic peptide (BNP), and C-type natriuretic peptide (CNP). DNP-like immunoreactivity (DNP-LI) was reported to be present...
متن کاملNatriuretic peptide receptors and neutral endopeptidase in mediating the renal actions of a new therapeutic synthetic natriuretic peptide dendroaspis natriuretic peptide.
OBJECTIVES The objectives of the current study were to define for the first time the roles of the natriuretic peptide (NP) receptors and neutral endopeptidase (NEP) in mediating and modulating the renal actions of Dendroaspis natriuretic peptide (DNP), a new therapeutic synthetic NP. BACKGROUND Recent reports have advanced the therapeutic potential of a newly described synthetic NP called DNP...
متن کاملNovel snake venom ligand dendroaspis natriuretic peptide is selective for natriuretic peptide receptor-A in human heart: downregulation of natriuretic peptide receptor-A in heart failure.
The natriuretic peptides are considered to be cardioprotective; however, their receptors have not been identified in human myocardium using radiolabeled analogs. Dendroaspis natriuretic peptide (DNP) has been recently identified as a new member of this peptide family and is thought to be less susceptible to enzymatic degradation. Therefore, we have developed the novel radiolabeled analog [125I]...
متن کاملConcentrations of brain natriuretic peptide in treated congestive heart failure.
CLINICALCHEMISTRY, Vol.37, No. 5, 1991 765 (sandwich) assays. II. Studies on the nature of the “high-dose hook-effect.” Immunochemistry 1978;15:77-82. 9. Miles LEM, Lipschitz DA, Bieber CP, et al. Measurement of serum ferritin by a 2-site immunoradiometric assay. Anal Biochem 1974;61:209-24. 10. Green B., Watson LB., Saab GA, et al. “Normal” serum ferritin-a caution. Blood 1977;50:545-7. 11. Ry...
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ژورنال
عنوان ژورنال: Hypertension
سال: 2001
ISSN: 0194-911X,1524-4563
DOI: 10.1161/01.hyp.37.4.1089